DISCOVERIES REPORTS (ISSN 2393249X), 2022, volume 5


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CITATION: Ahammed MR, Joshi A, Kafle S, Mumtaz A, Thakkar K, Nasir YM et al. Role of melatonin on renal ischemia-reperfusion injury. Discoveries Reports 2022; 5(1): e29. DOI: 10.15190/drep.2022.3

Role of melatonin on renal ischemia-reperfusion injury

Md Ripon Ahammed1,*, Amey Joshi1, Sunam Kafle1, Aqsa Mumtaz1, Keval Thakkar1, Yusra Minahil Nasir1, Subarna Shrestha1, Heeya Shah1, Gaayathri Krishnan1, Fariha Noor Ananya1, Eugenio Angueira2

(1) Division of Clinical and Translational Research, Larkin Community Hospital, South Miami, FL, USA
(2) Larkin Community Hospital, South Miami, FL, USA

* Corresponding author: Dr. Md Ripon Ahammed, Division of Clinical and Translational Research, Larkin Community Hospital, South Miami, FL, USA. Email:


Acute kidney injury secondary to ischemia-reperfusion injury can occur after an infarction, sepsis or a renal transplantation. If not treated promptly, it can be fatal due to widespread oxidative tissue injury and inflammation. Melatonin, previously known for its circadian regulatory properties, has been of recent interest in preventing and treating renal ischemic reperfusion injury because of its antioxidant and anti-inflammatory properties. In this review we summarize the pharmacokinetic properties of melatonin, the pathophysiology of renal ischemic reperfusion injury and how we can use melatonin to prevent renal ischemic reperfusion injury. Furthermore, we discuss the recent clinical trials evaluating the impact of melatonin on the renal ischemic reperfusion injury. This review summarizes the current evidence on the beneficial effects of melatonin and prospects using melatonin to improve patient care and prevent fatalities from acute kidney injury. The initial data on the effects of melatonin in preventing and treating renal ischemic reperfusion injury looks promising. However, more randomized control trials on humans need to be conducted to evaluate the complete impact of melatonin on the renal ischemic reperfusion injury, the correct formulations, dosage and the possible adverse effects. Only then can melatonin be used as an agent to prevent renal ischemic reperfusion injury.


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