DISCOVERIES REPORTS (ISSN 2393249X), 2023, volume 6
ORIGINAL ARTICLE
CITATION: Dindere ME. New FDA-approved SGLT2 Inhibitor Bexagliflozin for Type 2 Diabetes Therapy. Discoveries Reports 2023; e40. DOI: 10.15190/drep.2023.4
New FDA-approved SGLT2 Inhibitor Bexagliflozin for Type 2 Diabetes Therapy
Mihaela Elisabeta Dindere 1,2,3 *
1 Ludwig Maximilians University, Munich, Germany
2 Victor Babes National Institute of Pathology, Bucharest, Romania
3 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
* Corresponding authors:
Mihaela Elisabeta Dindere, Victor Babes National Institute of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest Romania: Email: dinderemihaela2001@gmail.com
Abstract
Type 2 diabetes mellitus (T2DM) is an escalating global challenge, standing out as a prominent public health concern with profound implications for healthcare costs. Recent data reveals the prevalence of diabetes in adults reaching approximately 537 million in 2021, expected to rise to 643 million by 2030. Moreover, it adversely impacts functional capabilities of patients, leading to extensive morbidity and premature mortality. Between 2000 and 2019, age-standardized mortality rates for diabetes increased by 3%, attributed to alarming unhealthy lifestyles, heightened body mass indexes, and health complications due to elevated glycemia, and raising an absolute need for effective treatment approaches. Over the last decade, Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors have gained popularity as primary medications for T2DM. A noteworthy addition to this class of drugs is TheracosBio’s Brenzavvy (bexagliflozin), an FDA-approved oral SGLT2 inhibitor introduced in January 2023. Thus, phase 3 studies demonstrated bexagliflozin’s efficacy in significantly reducing hemoglobin A1c and fasting blood sugar levels over 24 weeks. As a well-tolerated medication, bexagliflozin exhibits positive effects even in T2DM patients with major adverse cardiovascular events and impaired renal function. Its potential to enhance the overall functionality and life quality of affected individuals, while mitigating the financial burden associated with diabetes care, positions bexagliflozin as a promising advancement in the management of type 2 diabetes mellitus.
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