New FDA approved therapy for Helicobacter pylori infection
DISCOVERIES REPORTS (ISSN 2393249X), 2022, volume 5


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CITATION: Bucur DE. New FDA approved therapy for Helicobacter pylori infection. Discoveries 2022, 5(2): e34. DOI: 10.15190/d.2022.8

New FDA approved therapy for Helicobacter pylori infection

Daniel Erik Bucur 1,*

Cantemir Voda National College, Bucharest, Romania

* Corresponding author: Daniel Erik Bucur, Cantemir Voda National College, Str. Viitorului 60, Bucharest, 030167, Romania; Email:;


Approximately 90% of the gastric cancer cases have been linked to Helicobacter pylori (H. pylori). H pylori remains a real threat, infecting approximately 4 billion people in 2015 around the globe. It is also known to colonize the gastrointestinal mucosa of almost half the human population. Currently, the most common treatment for H. pylori infection is the first line clarithromycin–based triple therapy or a quadruple therapy replacing clarithromycin with new antibiotics. Vonoprazan-based triple therapy has been reported to have greater efficacy than a proton pump inhibitor-based triple therapy for H. pylori. In 2022, the U.S. Food and Drugs Administration approved the vonoprazan-based triple and dual therapies. This latest treatment represents a proof of concept for the development of even more efficient and advanced treatments targeting H. pylori, in order to significantly decrease gastrointestinal-related pathologies.

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