DISCOVERIES REPORTS (ISSN 2393249X), 2021, volume 4

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CITATION: Miglani S, Ansari I, Boreak N, Vadav V. Integrated approach for management of oro-dental manifestations in survivors of Stevens-Johnson syndrome and toxic epidermal necrolysis. Discoveries Reports, 2021; 4: e23. DOI: 10.15190/drep.2021.8 Submitted: May 19, 2021; Revised: June 21, 2021; Accepted: June 30, 2021; Published: 2021;

Integrated approach for management of oro-dental manifestations in survivors of Stevens-Johnson syndrome and  toxic epidermal necrolysis

Sanjay Miglani (1), Irfan Ansari (1), Nezar Boreak (2), Vijay Vadav (1,*)

(1) Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
(2) Department of Restorative Dental Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia 

* Corresponding author: Vijay Vadav, Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, 110025, India; Email:


Stevens-Johnson syndrome and toxic epidermal necrolysis are severe muco-cutaneous reactions seen in clinical practice, usually due to adverse reactions to certain drugs, such as sulfonamides, anticonvulsants, and non-steroidal anti-inflammatory drugs. They are characterized by the eruption of blisters and epithelial sloughing, which can turn into a life-threatening situation. Acute and chronic complications of Stevens-Johnson syndrome and toxic epidermal necrolysis are well documented in the literature, and it is recognized that survivors may develop oro-dental abnormalities as a long-term complication of Stevens-Johnson syndrome. To date and to our knowledge, there is no publication available emphasizing the importance of an integrated approach amongst dental specialties for the management of oro-dental complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. This review aims to provide an update on a wide range of oro-dental sequelae as a long-term complication following an acute episode of Stevens-Johnson syndrome and toxic epidermal necrolysis, along with an emphasis on the need of an interdisciplinary collaboration of dental specialties for early diagnosis and management of such cases.


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