DISCOVERIES REPORTS (ISSN 2393249X), 2026, volume 9
ORIGINAL ARTICLE
CITATION: Gurjar P, Nishith N, Sancheti S, Somal P, Sharma A, Nongthombam G, Pawar RN, Prasad P. Rare Presentation of Adult T-cell Leukaemia/Lymphoma Mimicking Hodgkin Lymphoma: A Case Report. Discoveries Reports 2026; 9(1): e50. DOI: 10.15190/drep.2026.5
Rare Presentation of Adult T-cell Leukaemia/Lymphoma Mimicking Hodgkin Lymphoma: A Case Report
Zachariah Chowdhury 1,2, Paramita Rudra Pal 1,2, *, Neha Singh 1,2, Ajita Verma 1,2
1 Department of Oncopathology, Homi Bhabha Cancer Hospital (HBCH) and Mahamana Pandit Madan Mohan Malviya Cancer Centre (MPMMCC), Sundarpur, Varanasi, India
2 Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Varanasi, India
* Corresponding author: Dr. Paramita Rudra Pal, Department of Oncopathology, Mahamana Pandit Madan Mohan Malviya Cancer Centre (MPMMCC) Sundar Bagiya Colony, Sundarpur, Varanasi, UttaPradesh, India; Email: imtiazbashir7@gmail.com
Abstract
Dedifferentiated endometrial carcinoma (DEC) is a rare and aggressive subtype of endometrial cancer characterized by the coexistence of differentiated and undifferentiated tumor components. We report a case of synchronous DEC and a benign ovarian Brenner tumor in a 68-year-old postmenopausal woman presenting with abnormal uterine bleeding. Histopathological examination revealed a biphasic tumor composed of FIGO grade 2 endometrioid carcinoma and an undifferentiated carcinoma with rhabdoid features. The tumor was accurately staged as pT1aN0, corresponding to FIGO stage IA. This case highlights limitations of endometrial biopsy in diagnosing DEC due to under-sampling of the undifferentiated component. Immunohistochemistry showed diffuse cytokeratin positivity and moderate estrogen receptor expression with retained INI1 and wild-type p53. The coexistence of DEC with a benign ovarian Brenner tumor is exceptionally rare and poses diagnostic and pathogenetic considerations.
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DOI: 10.15190/drep.2026.3
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